The Portuguese team, which had won 2-0 in Belgium in the first leg, thrashed Bruges on their home ground and qualified for the next phase. The Argentinian defender, booked, was replaced after 73 minutes.
Benfica, from Portugal, with the defending world champion Nicolás Otamendi as the starter, also qualified for the next Champions League stage with a 5-1 win, at home, against Bruges, from Belgium.
The Portuguese Rafa (PT 38m), Goncalo Ramos (PT 45+2m and ST 12m) and João Mario (ST 26m, penalty) and the Brazilian David Neres (ST 32m), they scored for the local, while the Dutchman Bjorn Meijer discounted for the Belgian team (ST 43m).
The Lisbon city club won the series handily after a 2-0 win in the first leg.
All match numbers
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