Diabetes: the brain is involved in its development

Diabetes: the brain is involved in its development

Type 2 diabetes is one of the most widespread diseases worldwide. The number of those affected increases from year to year. So far, research has assumed that the central nervous system is not involved in the development of the disease.

A French working group from the “Institut national de la santé et de la recherche médicale” (Inserm) has now found that the brain is very much involved in the development of type 2 diabetes. The focus is on an impaired transport of the hormone leptin, which in healthy people has a satiating and appetite-suppressing effect in the brain.

In order to fulfill this task, leptin has to bind to so-called LepR receptors. These receptors sit on the surface of special transport cells. Without this, leptin cannot transmit satiety information to the brain. This transport is disrupted in the case of obese people. You don’t feel full. Obese people are particularly at risk of developing diabetes.

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