A team of researchers investigated the question of whether hormone replacement therapy during menopause increases the risk of dementia in the long term. The five most important questions and answers.
Why can one hormone how estrogen actually affects brain performance?
Actually, when people talk colloquially about estrogen, they almost always mean “estradiol”, sometimes “estradiol” or “E2” for short. Estradiol is the most effective representative of these messenger substances called estrogens – and despite its production in the ovaries, it is by no means only found in the female body. In men, this estrogen is produced by chemical conversion of the sex hormone testosterone produced in the testicles. Estradiol can also cross the blood-brain barrier. And the brain can even produce estradiol itself. In addition, receptors (biochemically precisely matching contact points) are also widespread in the brain.
Source: Stern

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