Viennese biologists report broken energy generators in human cells with at least two signals. In the case of Parkinson’s illness, where the recently deceased rock singer Ozzy Osbourne suffered, defects accelerate the loss of nerve cells in the disposal of these “mitochondria”. For Parkinson’s treatment, a signal path could possibly push therapeutically if the other is broken, the researchers explain.
Her study appeared in the journal “Nature Cell Biology”. So far, a protein called “FIP200” has been considered essential for mitochondria recycling, according to the researchers around Sascha Martens from the Max Perutz Labs at the University of Vienna. With so-called “wipi protein fabrics”, however, they have now discovered a parallel trigger mechanism. “This could pave the way for therapies that specifically activate a signal path to compensate for defects in the other,” they wrote: “This has long-term potential for the treatment of Parkinson’s disease.”
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Parkinson’s, a neurodegenerative disease that is still not curable today, primarily die dopamine-producing nerve cells in the Middle Brain. The lack of messenger dopamine leads to movement disorders. Medicinal and non-drug therapies are available to treat the symptoms
Source: Nachrichten
