Now the first patent has been filed for the formula of a substance that will actively suppress the RNA polymerase of coronavirus, Izvestia was told at the Center. N.F. Gamalei. This compound could form the basis of a future drug for COVID-19.
At the Center. N.F. The Gamaleys told Izvestia that molecular docking will be used to create a future drug. This is a molecular modeling method that allows one to predict the most favorable orientation and conformation of the molecule for the formation of stable binding to the target (part of the coronavirus). Conformation is the spatial arrangement of atoms in a molecule of a certain configuration. And this arrangement can be changed. Thus, scientists are trying to ensure that the drug is optimally suited to the target, like a key to a lock.
To select the desired molecule, experts went through half a million compounds.
“Now we have selected 25–30, which are undergoing targeted modification, in order to then select two or three, and maybe even one, which would bind with high efficiency to the target we have defined, suppressing virus multiplication in cell culture by five orders of magnitude. If this succeeds, then there is hope that when we reach a person, we will retain at least three or four orders of magnitude of such suppressive activity, ”the director of the Center. N.F. Gamalei Alexander Gunzburg.
Molecule of Success: Gamaleia Center Disclosed Details of COVID Chemotherapy Development
Source: IZ
Jane Stock is a technology author, who has written for 24 Hours World. She writes about the latest in technology news and trends, and is always on the lookout for new and innovative ways to improve his audience’s experience.
