The 53BP1 protein is involved in the DNA protection mechanism that can prevent premature aging of the body, as well as the formation of cancer cells. This is evidenced by the research data of scientists from the Case University of the Western Reserve Region (USA), published on January 18 in the journal Nature Communication.
It is noted that the 53BP1 protein, which is involved in a previously unknown mechanism, is known as a molecule that can play an important role in repairing DNA double-strand breaks, which, in turn, are capable of destroying the cell due to genome rearrangement.
American scientists concluded that 53BP1 also interacts with heterochromatin, which maintains the structure of DNA and regulates gene activity, the loss of heterochromatin, in the formation of which the HP1α protein is involved, and provokes premature aging.
At the same time, the article says, 53BP1, together with HP1α, undergoes a liquid-liquid phase separation, which plays a direct role in the regulation of DNA.
To find out, the scientists blocked the functions of 53BP1 and looked at how this affected heterochromatin, and also identified specific parts of the protein that are involved in phase separation. It turned out that some mutant forms of 53BP1 continued to regulate the packing of heterochromatin and protect cells from aging, which indicated the separation of functions between different parts of the molecule.
Earlier, on January 19, it was reported that Chinese scientists through research found that the risk of premature death is indicated by a significant difference between the real age of a person and the biological age of the retina of his eyes.
Since 2006, researchers have studied the fundus images of about 47,000 people aged 40 to 69, processing the data using machine learning algorithms.
The experts concluded that the risk of death in the next 11 years increases by 2-3% if the age of the retina is one year older than the age of the person.
Thus, scientists have found that the difference in the state of the retina and the biological age of a person can be a potential biomarker of aging.
Source: IZ
Jane Stock is a technology author, who has written for 24 Hours World. She writes about the latest in technology news and trends, and is always on the lookout for new and innovative ways to improve his audience’s experience.
